Innovation underpins competitiveness, is crucial to addressing societal challenges, and its support has become a major public policy goal. But what really works in innovation policy, and why? This Handbook, compiled by leading experts in the field, is the first comprehensive guide to understanding the logic and effects of innovation polices. The Handbook develops a conceptualisation and typology of innovation policies, presents meta-evaluations for 16 key innovation policy instruments and analyses evidence on policy-mix. For each policy instrument, underlying rationales and examples are presented, along with a critical analysis of the available impact evidence. Providing access to primary sources of impact analysis, the book offers an insightful assessment of innovation policy practice and its evaluation. The Handbook's final chapter draws overall conclusions, reflects on the merits and limits of evaluation and impact analysis in innovation policy and suggests tangible improvements. This Handbook is an indispensable source for researchers, analysts, students and practitioners of innovation policy at all levels, as well as all those interested in policy analysis and evaluation more generally.